You can lose your money in a bull run, and whether you get profit or loss, it depends on what you do like trading or investment and if trading, is it Spot, Margin or Futures.

With investment, is it an investment with your own money, not from a loan?

These things will decide that will your trading or investment get a margin call, loan expiration or position liquidation. If you use risky trading types like Margin or Futures, or if you invest with loaned money, you have high risk of losing money. No technical indicators can save you even the market is bullish.